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KMID : 0371619920080010145
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Journal of Wonkwang Medical Science
1992 Volume.8 No. 1 p.145 ~ p.154
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The Role of Postoperative Radiotherapy in the Management of Stage C Rectal Cancer
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Abstract
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From January 1985 to December 1987, 66 patients with Modified Astler Coller stage C rectal cancer were retrospectively analysed. All patients received complete surgical resection followed by postoperative radiotherapy. The patients were divided
into two
groups as follows: I.Low-dose irradiation group(28 patients received less than 5500cGy in 6 weeks ; Mean 48.7 Gy), II,High-dose irradiation group (38 patients received more than 5500 cGy in 6-8 weeks ; Mean 57.7 Gy). Main purpose of this study is
to
determine whether or not there was differences in local control and survival between low-dose and high-dose postoperative irradiation group.
Low-dose postoperative irradiation group had a 45.0% of 3-year local recurrence free survival and 30.3% of 3-year disease free survival. On the other hand, High-dose postoperative irradiation group had a 69.0% of 3-year local recurrence free
survival
and 60.2% of 3-year disease free survival.
The complications for postoperative radiotherapy had no significant difference between two groups and were acceptable in all patients. on the basis of this study, when considering adjuvant postoperative radiotherapy in stage C rectal cancer, at
least
minimum of 5500 cGy or more should be delivered in order to have maximum benefit.
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KEYWORD
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